Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines.

Skalska, Lenka

Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines. [electronic resource] - PLoS pathogens Feb 2013 - e1003187 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1553-7374

10.1371/journal.ppat.1003187 doi


Antigens, Viral--genetics
B-Lymphocytes--virology
Cell Line
Cell Proliferation
Cell Survival
Cyclin-Dependent Kinase Inhibitor p16--genetics
Epigenetic Repression--genetics
Epstein-Barr Virus Infections--immunology
Epstein-Barr Virus Nuclear Antigens--genetics
Genetic Loci
Herpesvirus 4, Human--immunology
Humans
Lymphocyte Activation
Oligonucleotide Array Sequence Analysis
Phosphorylation
Primary Cell Culture
Virus Latency