Inhibition of overactive transforming growth factor-β signaling by prostacyclin analogs in pulmonary arterial hypertension.

Ogo, Takeshi

Inhibition of overactive transforming growth factor-β signaling by prostacyclin analogs in pulmonary arterial hypertension. [electronic resource] - American journal of respiratory cell and molecular biology Jun 2013 - 733-41 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1535-4989

10.1165/rcmb.2012-0049OC doi


Animals
Bone Morphogenetic Protein Receptors, Type II--genetics
Cell Proliferation--drug effects
Codon, Nonsense
Epoprostenol--analogs & derivatives
Familial Primary Pulmonary Hypertension
HEK293 Cells
Humans
Hypertension, Pulmonary--metabolism
Lung--drug effects
MAP Kinase Signaling System
Male
Mice
Monocrotaline--pharmacology
Myocytes, Smooth Muscle--drug effects
Phosphorylation
Protein Serine-Threonine Kinases--genetics
Rats
Rats, Sprague-Dawley
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta--genetics
Smad3 Protein--genetics
Transforming Growth Factor beta1--antagonists & inhibitors