Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner.

Meng, Jingjing

Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner. [electronic resource] - PloS one 2013 - e54040 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

1932-6203

10.1371/journal.pone.0054040 doi


Analgesics, Opioid--pharmacology
Animals
Azepines--pharmacology
Bacterial Translocation--drug effects
Blotting, Western
Cell Line
Colon--drug effects
Epithelium--drug effects
Ileum--drug effects
Intestinal Mucosa--metabolism
Intestines--drug effects
Liver--drug effects
Lymph Nodes--drug effects
Mesentery
Mice
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Fluorescence
Morphine--pharmacology
Myosin-Light-Chain Kinase--antagonists & inhibitors
Naphthalenes--pharmacology
Receptors, Opioid, mu--genetics
Reverse Transcriptase Polymerase Chain Reaction
Tight Junctions--drug effects
Toll-Like Receptor 2--genetics
Toll-Like Receptor 4--genetics
Zonula Occludens-1 Protein--metabolism