Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α (TNF-α) conjugate for therapeutic application.
Dai, ChuanYun
Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α (TNF-α) conjugate for therapeutic application. [electronic resource] - Science China. Life sciences Jan 2013 - 51-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1869-1889
10.1007/s11427-012-4431-7 doi
Animals
Antineoplastic Agents--chemistry
Cathepsin B--antagonists & inhibitors
Cell Line, Tumor
Cell Survival--drug effects
Dipeptides--chemistry
Dose-Response Relationship, Drug
Drug Compounding
Drug Evaluation, Preclinical
Glycopeptides--pharmacology
Humans
Hydrogen-Ion Concentration
Leucine--analogs & derivatives
Lysosomes--enzymology
Male
Mice
Mice, Inbred C57BL
Neoplasms, Experimental--drug therapy
Pepstatins--pharmacology
Polyethylene Glycols--chemistry
Protease Inhibitors--pharmacology
Rats
Time Factors
Tumor Burden--drug effects
Tumor Necrosis Factor-alpha--chemistry
Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α (TNF-α) conjugate for therapeutic application. [electronic resource] - Science China. Life sciences Jan 2013 - 51-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1869-1889
10.1007/s11427-012-4431-7 doi
Animals
Antineoplastic Agents--chemistry
Cathepsin B--antagonists & inhibitors
Cell Line, Tumor
Cell Survival--drug effects
Dipeptides--chemistry
Dose-Response Relationship, Drug
Drug Compounding
Drug Evaluation, Preclinical
Glycopeptides--pharmacology
Humans
Hydrogen-Ion Concentration
Leucine--analogs & derivatives
Lysosomes--enzymology
Male
Mice
Mice, Inbred C57BL
Neoplasms, Experimental--drug therapy
Pepstatins--pharmacology
Polyethylene Glycols--chemistry
Protease Inhibitors--pharmacology
Rats
Time Factors
Tumor Burden--drug effects
Tumor Necrosis Factor-alpha--chemistry