Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.

Deprez-Poulain, Rebecca

Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors. [electronic resource] - Journal of medicinal chemistry Dec 2012 - 10909-17 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm301506h doi


Aminopeptidases--antagonists & inhibitors
Animals
Antimalarials--blood
Cell Line
Drug Resistance
Female
Humans
Malaria--drug therapy
Malonates--blood
Metalloproteases--antagonists & inhibitors
Mice
Molecular Docking Simulation
Plasmodium berghei
Plasmodium falciparum--drug effects
Protein Binding
Protozoan Proteins--antagonists & inhibitors
Rats
Solubility
Stereoisomerism
Structure-Activity Relationship
Tissue Distribution
Zinc