SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.

Forsyth, Timothy

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors. [electronic resource] - Bioorganic & medicinal chemistry letters Dec 2012 - 7653-8 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2012.10.007 doi


Animals
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Cell Proliferation--drug effects
Crystallography, X-Ray
Dogs
Dose-Response Relationship, Drug
Haplorhini
High-Throughput Screening Assays
Janus Kinase 2--antagonists & inhibitors
Mice
Mice, Nude
Models, Molecular
Molecular Structure
Neoplasms, Experimental--drug therapy
Proline--administration & dosage
Protein Kinase Inhibitors--administration & dosage
Pyrimidines--administration & dosage
Rats
Structure-Activity Relationship
Xenograft Model Antitumor Assays