Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells.

Jehle, J

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells. [electronic resource] - British journal of pharmacology Mar 2013 - 1215-29 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-5381

10.1111/bph.12002 doi


Action Potentials--drug effects
Animals
Cells, Cultured
Ether-A-Go-Go Potassium Channels--antagonists & inhibitors
HEK293 Cells
Humans
Hypnotics and Sedatives--pharmacology
Induced Pluripotent Stem Cells--cytology
Long QT Syndrome--chemically induced
Myocytes, Cardiac--drug effects
Oocytes--drug effects
Potassium Channel Blockers--pharmacology
Pyridines--pharmacology
Recombinant Proteins
Xenopus laevis
Zolpidem