Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.

Simpson, Peter D

Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant. [electronic resource] - PloS one 2012 - e40100 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0040100 doi


Animals
B-Lymphocytes--drug effects
Base Sequence
Cell Line
DNA Methylation--drug effects
Epigenesis, Genetic--drug effects
Genes, Reporter
HIV Infections--genetics
HLA-B Antigens--genetics
Haplotypes--genetics
Homozygote
Humans
Lipopolysaccharides--pharmacology
Luciferases--metabolism
Lymphocyte Activation--drug effects
Mice
Molecular Sequence Data
Monocytes--cytology
Polymorphism, Single Nucleotide--genetics
Promoter Regions, Genetic--genetics
Protein Binding--drug effects
RNA, Messenger--genetics
Software
Solubility
Tetradecanoylphorbol Acetate--pharmacology
Transcription Factors--metabolism
Tumor Necrosis Factor-alpha--biosynthesis