Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.

Balmer, Nina V

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. [electronic resource] - Human molecular genetics Sep 2012 - 4104-14 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2083

10.1093/hmg/dds239 doi


Abnormalities, Drug-Induced--genetics
Antigens, Differentiation--genetics
Basic Helix-Loop-Helix Transcription Factors--genetics
Cell Differentiation--drug effects
Cells, Cultured
Embryonic Stem Cells--metabolism
Epigenesis, Genetic--drug effects
Eye Proteins--genetics
Histone Deacetylase Inhibitors--pharmacology
Histones--metabolism
Homeodomain Proteins--genetics
Humans
Hydroxamic Acids--pharmacology
Methylation
Nanog Homeobox Protein
Neural Plate--embryology
Neural Stem Cells--metabolism
Neuroepithelial Cells--metabolism
Octamer Transcription Factor-3--genetics
Oligonucleotide Array Sequence Analysis
PAX6 Transcription Factor
Paired Box Transcription Factors--genetics
Principal Component Analysis
Promoter Regions, Genetic
Protein Processing, Post-Translational
Repressor Proteins--genetics
Transcription, Genetic
Transcriptome
Valproic Acid--adverse effects