Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease.

Siddiqui, Almas

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. [electronic resource] - Free radical biology & medicine Aug 2012 - 993-1003 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1873-4596

10.1016/j.freeradbiomed.2012.05.024 doi


Aged
Animals
Cell Nucleus--metabolism
Chromatin--metabolism
Chromatin Immunoprecipitation
Electron Transport Complex I--metabolism
Heat-Shock Proteins--genetics
Humans
Mice
Mice, Transgenic
Middle Aged
Mitochondria--metabolism
Oxidative Stress
PC12 Cells
Parkinson Disease--metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Promoter Regions, Genetic
Protein Binding
Rats
Transcription Factors--genetics
alpha-Synuclein--metabolism