Structural insights into the catalytic active site and activity of human Nit2/ω-amidase: kinetic assay and molecular dynamics simulation.

Chien, Chin-Hsiang

Structural insights into the catalytic active site and activity of human Nit2/ω-amidase: kinetic assay and molecular dynamics simulation. [electronic resource] - The Journal of biological chemistry Jul 2012 - 25715-26 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M111.259119 doi


Amino Acid Sequence
Amino Acid Substitution
Aminohydrolases--biosynthesis
Animals
Asparagine--analogs & derivatives
Catalytic Domain
Conserved Sequence
Humans
Hydrolysis
Ketoglutaric Acids--chemistry
Kinetics
Mice
Molecular Dynamics Simulation
Molecular Sequence Data
Mutagenesis, Site-Directed
Protein Binding
Protein Structure, Quaternary
Protein Structure, Secondary
Recombinant Proteins--biosynthesis
Sequence Deletion
Structural Homology, Protein
Substrate Specificity
Surface Properties
Thermodynamics