Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo.

Miyoshi, Seigo

Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo. [electronic resource] - International journal of oncology Aug 2012 - 449-56 p. digital

Publication Type: Journal Article

1791-2423

10.3892/ijo.2012.1462 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Butadienes--pharmacology
Cell Proliferation--drug effects
Chromones--pharmacology
Drug Synergism
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
MAP Kinase Kinase Kinases--antagonists & inhibitors
MAP Kinase Signaling System--drug effects
Male
Mesothelioma--drug therapy
Mice
Mice, SCID
Morpholines--pharmacology
Nitriles--pharmacology
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Pleural Neoplasms--drug therapy
Tumor Burden--drug effects
Tumor Cells, Cultured
Xenograft Model Antitumor Assays