Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy.

Elrashidy, Rania A

Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy. [electronic resource] - The Journal of pharmacy and pharmacology Jun 2012 - 862-71 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2042-7158

10.1111/j.2042-7158.2012.01508.x doi


Amides--pharmacology
Animals
Antihypertensive Agents--pharmacology
Cardiomyopathies--drug therapy
Diabetic Nephropathies--complications
Disease Models, Animal
Drug Therapy, Combination
Fibrosis--prevention & control
Fumarates--pharmacology
Gene Expression Regulation--drug effects
Hypoglycemic Agents--pharmacology
Lipid Peroxidation--drug effects
Male
Matrix Metalloproteinase 2--genetics
Myocardium--metabolism
Nephrectomy
Oxidative Stress--drug effects
Pioglitazone
Rats
Rats, Wistar
Streptozocin
Thiazolidinediones--pharmacology
Tissue Inhibitor of Metalloproteinase-2--genetics
Transforming Growth Factor beta1--genetics