Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.

Lacey, David L

Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab. [electronic resource] - Nature reviews. Drug discovery May 2012 - 401-19 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

1474-1784

10.1038/nrd3705 doi


Animals
Antibodies, Monoclonal--pharmacology
Antibodies, Monoclonal, Humanized
Bone Resorption--physiopathology
Bone and Bones--metabolism
Denosumab
Drug Design
Humans
Osteoclasts--physiology
Osteoprotegerin--metabolism
RANK Ligand--antagonists & inhibitors
Receptor Activator of Nuclear Factor-kappa B--metabolism
Signal Transduction