Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective.
Cippitelli, Andrea
Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective. [electronic resource] - Addiction biology Jan 2014 - 27-36 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1369-1600
10.1111/j.1369-1600.2012.00451.x doi
Adrenalectomy
Alcohol-Induced Disorders, Nervous System--etiology
Alcoholic Intoxication--metabolism
Analysis of Variance
Animals
Binge Drinking--complications
Cholesterol--administration & dosage
Corticosterone--administration & dosage
Dentate Gyrus--drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Implants--administration & dosage
Entorhinal Cortex--drug effects
Ethanol--administration & dosage
Fluoresceins
Hormone Antagonists--administration & dosage
Hypothalamo-Hypophyseal System--drug effects
Male
Mifepristone--administration & dosage
Neuroprotective Agents
Pituitary-Adrenal System--drug effects
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, Glucocorticoid--antagonists & inhibitors
Silver Staining
Stress, Physiological--drug effects
Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective. [electronic resource] - Addiction biology Jan 2014 - 27-36 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1369-1600
10.1111/j.1369-1600.2012.00451.x doi
Adrenalectomy
Alcohol-Induced Disorders, Nervous System--etiology
Alcoholic Intoxication--metabolism
Analysis of Variance
Animals
Binge Drinking--complications
Cholesterol--administration & dosage
Corticosterone--administration & dosage
Dentate Gyrus--drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Implants--administration & dosage
Entorhinal Cortex--drug effects
Ethanol--administration & dosage
Fluoresceins
Hormone Antagonists--administration & dosage
Hypothalamo-Hypophyseal System--drug effects
Male
Mifepristone--administration & dosage
Neuroprotective Agents
Pituitary-Adrenal System--drug effects
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, Glucocorticoid--antagonists & inhibitors
Silver Staining
Stress, Physiological--drug effects