Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway.

Cao, Qi

Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway. [electronic resource] - American journal of physiology. Cell physiology Jun 2012 - C1731-40 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1522-1563

10.1152/ajpcell.00213.2011 doi


Caco-2 Cells
Cell Polarity
Cell Proliferation
Colon--drug effects
Complement Activation--drug effects
Complement C5a--genetics
Epithelial Cells--drug effects
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
HT29 Cells
Humans
Immunity, Innate
Immunity, Mucosal
Inflammation--enzymology
Interleukin-8--genetics
Intestinal Absorption
Intestinal Mucosa--drug effects
MAP Kinase Signaling System--drug effects
Permeability
Phenotype
Protein Kinase Inhibitors--pharmacology
RNA, Messenger--metabolism
Receptor, Anaphylatoxin C5a
Receptors, Chemokine--genetics
Receptors, Complement--genetics
Time Factors
Up-Regulation