A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.

Kueck, Tonya

A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction. [electronic resource] - PLoS pathogens 2012 - e1002609 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1553-7374

10.1371/journal.ppat.1002609 doi


Antigens, CD--immunology
Cytoplasm--metabolism
Endosomes--metabolism
GPI-Linked Proteins--immunology
Gene Expression Regulation, Viral
HEK293 Cells--metabolism
HIV-1--drug effects
HeLa Cells--metabolism
Human Immunodeficiency Virus Proteins--genetics
Humans
Interferons--pharmacology
Jurkat Cells--metabolism
Protein Interaction Domains and Motifs--physiology
Protein Transport
Viral Regulatory and Accessory Proteins--genetics
Virion--metabolism
Virus Assembly
Virus Release--drug effects
Virus Replication