The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme.
Tsume, Yasuhiro
The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. [electronic resource] - Molecules (Basel, Switzerland) Mar 2012 - 3672-89 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1420-3049
10.3390/molecules17043672 doi
Amino Acids--metabolism
Antimetabolites, Antineoplastic--metabolism
Cathepsin B--metabolism
Cathepsin D--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Dipeptides--metabolism
Drug Stability
Enzyme Activation--drug effects
Floxuridine--metabolism
Gene Expression Profiling
Gene Expression Regulation, Neoplastic--drug effects
Humans
Pancreatic Neoplasms--drug therapy
Prodrugs--metabolism
The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. [electronic resource] - Molecules (Basel, Switzerland) Mar 2012 - 3672-89 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1420-3049
10.3390/molecules17043672 doi
Amino Acids--metabolism
Antimetabolites, Antineoplastic--metabolism
Cathepsin B--metabolism
Cathepsin D--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Dipeptides--metabolism
Drug Stability
Enzyme Activation--drug effects
Floxuridine--metabolism
Gene Expression Profiling
Gene Expression Regulation, Neoplastic--drug effects
Humans
Pancreatic Neoplasms--drug therapy
Prodrugs--metabolism