A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma.

Wigan, Matthew

A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma. [electronic resource] - The Journal of investigative dermatology Jun 2012 - 1681-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1523-1747

10.1038/jid.2012.41 doi


CDC2 Protein Kinase--metabolism
Cell Cycle Checkpoints--genetics
Cell Line, Tumor
Cyclin B1--metabolism
DNA Replication--genetics
DNA, Single-Stranded--genetics
DNA-Binding Proteins--physiology
Epidermal Cells
Epidermis--radiation effects
G1 Phase--genetics
G2 Phase--genetics
Humans
Melanoma--genetics
Mutation--genetics
S Phase--genetics
Skin Neoplasms--genetics
Ultraviolet Rays--adverse effects