Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy.

Clelland, Allyson Kara

Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy. [electronic resource] - Journal of cell science Jun 2012 - 2626-37 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1477-9137

10.1242/jcs.096867 doi


Cell Nucleus--drug effects
Fatty Acids, Unsaturated--pharmacology
Fibroblasts--drug effects
HeLa Cells
Humans
Models, Biological
Muscular Atrophy, Spinal--genetics
Protein Transport--drug effects
RNA Interference--drug effects
RNA Splicing--drug effects
RNA, Small Interfering--metabolism
Ribonucleoprotein, U1 Small Nuclear--metabolism
Ribonucleoproteins, Small Nuclear--metabolism
Spliceosomes--drug effects
Survival of Motor Neuron 1 Protein--metabolism