Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response.

Gong, Inna Y

Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response. [electronic resource] - European heart journal Nov 2012 - 2856-2464a p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1522-9645

10.1093/eurheartj/ehs042 doi


Adolescent
Adult
Area Under Curve
Aryl Hydrocarbon Hydroxylases--genetics
Aryldialkylphosphatase--genetics
Biotransformation--drug effects
Clopidogrel
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP3A--drug effects
Enzyme Inhibitors--pharmacokinetics
Humans
Midazolam--pharmacokinetics
Middle Aged
Platelet Aggregation--drug effects
Platelet Aggregation Inhibitors--pharmacokinetics
Polymorphism, Genetic--genetics
Ticlopidine--analogs & derivatives
Young Adult