Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.

Liu, Cheng-Ling

Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells. [electronic resource] - Marine drugs Jan 2012 - 242-257 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1660-3397

10.3390/md10010242 doi


ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics
Adenocarcinoma--drug therapy
Cell Line, Tumor
Colonic Neoplasms--drug therapy
Constitutive Androstane Receptor
Cytochrome P-450 CYP3A--genetics
Hep G2 Cells
Humans
Pregnane X Receptor
Promoter Regions, Genetic
RNA, Messenger--analysis
Receptors, Cytoplasmic and Nuclear--physiology
Receptors, Steroid--antagonists & inhibitors
Rifampin--pharmacology
Transcriptional Activation
Xanthophylls--pharmacology