Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability.

Onoue, Satomi

Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability. [electronic resource] - Drug metabolism and pharmacokinetics 2012 - 379-87 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1880-0920

10.2133/dmpk.dmpk-11-rg-101 doi


Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal--administration & dosage
Area Under Curve
Biological Availability
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Chromatography, Liquid
Crystallization
Crystallography, X-Ray
Drug Stability
Gastric Juice--chemistry
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Injections, Intravenous
Male
Metabolic Clearance Rate
Microscopy, Electron, Scanning
Microscopy, Polarization
Models, Biological
Polymethacrylic Acids--chemistry
Powder Diffraction
Rats
Rats, Sprague-Dawley
Solubility
Spectrometry, Mass, Electrospray Ionization
Spectroscopy, Fourier Transform Infrared
Spectroscopy, Near-Infrared
Technology, Pharmaceutical--methods
ortho-Aminobenzoates--administration & dosage