Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms.

Marchand, Benoît

Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. [electronic resource] - Carcinogenesis Mar 2012 - 529-37 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2180

10.1093/carcin/bgr309 doi


Anthracenes--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--biosynthesis
Bcl-2-Like Protein 11
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Glycogen Synthase Kinase 3--antagonists & inhibitors
Humans
Indoles--pharmacology
JNK Mitogen-Activated Protein Kinases--metabolism
MAP Kinase Signaling System
Maleimides--pharmacology
Membrane Proteins--biosynthesis
Pancreas--metabolism
Pancreatic Neoplasms--metabolism
Phosphorylation
Proto-Oncogene Proteins--biosynthesis
Proto-Oncogene Proteins c-akt--metabolism
Pyridines--pharmacology
Pyrimidines--pharmacology
RNA, Messenger--biosynthesis
Receptors, Death Domain--metabolism