Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.

Yun, Hee Jung

Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells. [electronic resource] - Molecular and cellular biochemistry Apr 2012 - 281-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1573-4919

10.1007/s11010-011-1180-z doi


Adenocarcinoma--enzymology
Animals
Antineoplastic Agents, Phytogenic--pharmacology
Apoptosis--drug effects
Benzocycloheptenes--pharmacology
Cell Cycle Proteins--metabolism
Checkpoint Kinase 2
Colonic Neoplasms--enzymology
Cyclin-Dependent Kinase Inhibitor p21--metabolism
DNA Breaks, Double-Stranded
DNA-Binding Proteins--metabolism
Fibroblasts--drug effects
G1 Phase Cell Cycle Checkpoints--drug effects
HT29 Cells
Histones--metabolism
Humans
Mice
Minichromosome Maintenance Complex Component 4
Nuclear Proteins--metabolism
Phosphorylation
Protein Serine-Threonine Kinases--metabolism
Signal Transduction--drug effects
Time Factors
Tumor Suppressor Protein p53--metabolism
cdc25 Phosphatases--metabolism