Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.
Shah, Dhaval K
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human. [electronic resource] - Journal of pharmacokinetics and pharmacodynamics Feb 2012 - 67-86 p. digital
Publication Type: Journal Article
1573-8744
10.1007/s10928-011-9232-2 doi
Adalimumab
Algorithms
Animal Structures--metabolism
Animals
Antibodies, Monoclonal--blood
Antibodies, Monoclonal, Humanized--blood
Antigens, Neoplasm--immunology
Area Under Curve
Blood--metabolism
Drug Evaluation, Preclinical--methods
Endosomes--metabolism
Extracellular Space--metabolism
Haplorhini
Histocompatibility Antigens Class I--genetics
Humans
Immunoglobulins, Intravenous--administration & dosage
Lymph--metabolism
Male
Mice
Mice, Knockout
Models, Biological
Neoplasms--immunology
Pinocytosis--physiology
Rats
Receptors, Fc--genetics
Tissue Distribution--drug effects
Xenograft Model Antitumor Assays
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human. [electronic resource] - Journal of pharmacokinetics and pharmacodynamics Feb 2012 - 67-86 p. digital
Publication Type: Journal Article
1573-8744
10.1007/s10928-011-9232-2 doi
Adalimumab
Algorithms
Animal Structures--metabolism
Animals
Antibodies, Monoclonal--blood
Antibodies, Monoclonal, Humanized--blood
Antigens, Neoplasm--immunology
Area Under Curve
Blood--metabolism
Drug Evaluation, Preclinical--methods
Endosomes--metabolism
Extracellular Space--metabolism
Haplorhini
Histocompatibility Antigens Class I--genetics
Humans
Immunoglobulins, Intravenous--administration & dosage
Lymph--metabolism
Male
Mice
Mice, Knockout
Models, Biological
Neoplasms--immunology
Pinocytosis--physiology
Rats
Receptors, Fc--genetics
Tissue Distribution--drug effects
Xenograft Model Antitumor Assays