Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.

Christianson, C A

Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. [electronic resource] - Neuroscience Jan 2012 - 199-210 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1873-7544

10.1016/j.neuroscience.2011.10.019 doi


Analysis of Variance
Animals
Anti-Inflammatory Agents, Non-Steroidal--therapeutic use
Calcium-Binding Proteins
Cells, Cultured
DNA-Binding Proteins--metabolism
Dipeptides--therapeutic use
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Inhibitors--therapeutic use
Enzyme-Linked Immunosorbent Assay--methods
Etanercept
Gene Expression Regulation--drug effects
Glial Fibrillary Acidic Protein--metabolism
Hydroxamic Acids--therapeutic use
Hyperalgesia--drug therapy
Immunoglobulin G--therapeutic use
Inflammation--chemically induced
Lipopolysaccharides
Male
Matrix Metalloproteinase 3--administration & dosage
Microfilament Proteins
Neuroglia--drug effects
Pain Measurement
Pain Threshold--drug effects
Physical Stimulation
Rats
Rats, Sprague-Dawley
Reaction Time--drug effects
Receptors, Tumor Necrosis Factor--therapeutic use
Spinal Cord--drug effects
Sulfonamides--therapeutic use
Time Factors
Tumor Necrosis Factors--metabolism