PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment.

Obermajer, Natasa

PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment. [electronic resource] - Cancer research Dec 2011 - 7463-70 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-11-2449 doi


Biphenyl Compounds--pharmacology
CD11b Antigen--genetics
Celecoxib
Cell Movement
Cells, Cultured
Chemokine CXCL12--genetics
Cyclooxygenase 2--genetics
Cyclooxygenase 2 Inhibitors--pharmacology
Dinoprostone--metabolism
Female
Flow Cytometry
Gene Expression Regulation, Neoplastic
Humans
Monocytes--drug effects
Myeloid Cells--drug effects
Ovarian Neoplasms--genetics
Prostaglandin Antagonists--pharmacology
Pyrazoles--pharmacology
Receptors, CXCR4--genetics
Receptors, Prostaglandin E, EP2 Subtype--antagonists & inhibitors
Receptors, Prostaglandin E, EP4 Subtype--antagonists & inhibitors
Sulfonamides--pharmacology
Tumor Cells, Cultured
Tumor Microenvironment--drug effects
Xanthones--pharmacology