Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts.

Zhou, Xiaodong

Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts. [electronic resource] - Arthritis research & therapy Aug 2011 - R128 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

1478-6362

10.1186/ar3435 doi


Biocatalysis
Blotting, Western
Cell Nucleus--enzymology
DNA Topoisomerases, Type I--metabolism
Female
Fibroblasts--enzymology
Humans
Immunohistochemistry
Immunoprecipitation
Male
RNA, Small Interfering
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Scleroderma, Systemic--enzymology
Sumoylation
Transfection