CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes.

Sag, Can M

CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes. [electronic resource] - Journal of molecular and cellular cardiology Nov 2011 - 749-59 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1095-8584

10.1016/j.yjmcc.2011.07.016 doi


Action Potentials--drug effects
Animals
Benzylamines--pharmacology
Blotting, Western
Calcium--metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2--antagonists & inhibitors
Diastole
Doxorubicin--adverse effects
Free Radical Scavengers--pharmacology
Gene Expression
Ion Transport--drug effects
Isoenzymes--antagonists & inhibitors
Melatonin--pharmacology
Mice
Microscopy, Fluorescence
Myocardial Contraction--drug effects
Myocytes, Cardiac--cytology
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Rats
Rats, Wistar
Reactive Oxygen Species--antagonists & inhibitors
Sarcoplasmic Reticulum--drug effects
Sulfonamides--pharmacology