Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR.

Gonçalves, António Pedro

Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR. [electronic resource] - Life sciences Sep 2011 - 371-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0631

10.1016/j.lfs.2011.07.004 doi


Antineoplastic Agents--pharmacology
Apoptosis
Carcinoma
Carcinoma, Papillary
Caspases--metabolism
Cell Proliferation--drug effects
Enzyme Activation
Glial Cell Line-Derived Neurotrophic Factor--metabolism
Humans
Membrane Potential, Mitochondrial--drug effects
Oncogene Protein v-akt--metabolism
Oncogene Proteins, Fusion--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation
Protein-Tyrosine Kinases--antagonists & inhibitors
Reactive Oxygen Species--metabolism
Signal Transduction
TOR Serine-Threonine Kinases--metabolism
Thyroid Cancer, Papillary
Thyroid Neoplasms--genetics
Tumor Cells, Cultured
Vanadates--pharmacology