Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice.

Cattaruzza, Fiore

Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. [electronic resource] - Gastroenterology Nov 2011 - 1864-74.e1-3 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1528-0012

10.1053/j.gastro.2011.07.035 doi


Animals
Cathepsin B--metabolism
Cathepsin L--metabolism
Cathepsins--metabolism
Colitis--chemically induced
Colon--metabolism
Crohn Disease
Disease Models, Animal
Gene Deletion
Hyperalgesia--etiology
Interleukin-10--genetics
Macrophages--metabolism
Magnetic Resonance Imaging
Mice
Mice, Inbred C57BL
Mice, Knockout
Nociceptors--metabolism
Piroxicam--adverse effects
Receptor, PAR-2--genetics
Signal Transduction--physiology
Visceral Pain--metabolism