Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells.

Zhu, Thant S

Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. [electronic resource] - Cancer research Sep 2011 - 6061-72 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-10-4269 doi


AC133 Antigen
Adaptor Proteins, Signal Transducing
Animals
Antigens, CD--metabolism
Brain Neoplasms--metabolism
Calcium-Binding Proteins--biosynthesis
Cell Growth Processes--physiology
Endothelial Cells--metabolism
Gene Knockdown Techniques
Glioblastoma--metabolism
Glycoproteins--metabolism
Humans
Intercellular Signaling Peptides and Proteins--biosynthesis
Intermediate Filament Proteins--metabolism
Membrane Proteins--biosynthesis
Mice
Neoplastic Stem Cells--metabolism
Nerve Tissue Proteins--metabolism
Nestin
Peptides--metabolism
RNA, Small Interfering--administration & dosage
Receptors, Notch--biosynthesis
Serrate-Jagged Proteins
Stem Cell Niche
Xenograft Model Antitumor Assays