Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Possemato, Richard
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. [electronic resource] - Nature Aug 2011 - 346-50 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-4687
10.1038/nature10350 doi
Animals
Biomarkers, Tumor--metabolism
Breast Neoplasms--enzymology
Cell Line, Tumor
Cell Proliferation
Citric Acid Cycle--physiology
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Genomics
Glutamic Acid--metabolism
Humans
Ketoglutaric Acids--metabolism
Melanoma--enzymology
Mice
Neoplasm Transplantation
Phosphoglycerate Dehydrogenase--genetics
RNA Interference
Serine--biosynthesis
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. [electronic resource] - Nature Aug 2011 - 346-50 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-4687
10.1038/nature10350 doi
Animals
Biomarkers, Tumor--metabolism
Breast Neoplasms--enzymology
Cell Line, Tumor
Cell Proliferation
Citric Acid Cycle--physiology
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Genomics
Glutamic Acid--metabolism
Humans
Ketoglutaric Acids--metabolism
Melanoma--enzymology
Mice
Neoplasm Transplantation
Phosphoglycerate Dehydrogenase--genetics
RNA Interference
Serine--biosynthesis