Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.

Massart, J

Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis. [electronic resource] - British journal of pharmacology Mar 2012 - 1361-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5381

10.1111/j.1476-5381.2011.01580.x doi


Adipocytes--drug effects
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Biomarkers--blood
Blood Glucose--drug effects
Cell Line, Tumor
Diabetes Mellitus, Type 2--genetics
Fatty Liver--genetics
Glucose--genetics
Glucose Tolerance Test--methods
Glucose Transporter Type 2--genetics
Glycolysis--drug effects
Humans
Inflammation--genetics
Intestinal Absorption--drug effects
Jejunum--drug effects
Lipids--blood
Lipogenesis--drug effects
Liver--drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Nuclear Proteins--genetics
Obesity--genetics
Oxidative Stress--drug effects
Pentoxifylline--pharmacology
Sodium-Glucose Transporter 1--genetics
Sterol Regulatory Element Binding Protein 1--genetics
Transaminases--blood
Transcription Factors--genetics
Triglycerides--blood