Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells.
Xu, Hai
Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Jul 2011 - 4425-38 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1557-3265
10.1158/1078-0432.CCR-10-3339 doi
Animals
Antineoplastic Agents--pharmacology
Carcinoma--metabolism
Carcinoma, Squamous Cell
Cell Line, Tumor
Cell Proliferation--drug effects
ErbB Receptors--antagonists & inhibitors
Female
Gefitinib
Head and Neck Neoplasms--metabolism
Hepatocyte Growth Factor--metabolism
Humans
Mice
Mice, SCID
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Neoplasm Invasiveness
Neoplasms, Squamous Cell--metabolism
Phosphorylation--drug effects
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Proto-Oncogene Proteins c-met--antagonists & inhibitors
Quinazolines--pharmacology
Signal Transduction--drug effects
Squamous Cell Carcinoma of Head and Neck
Transforming Growth Factor alpha--pharmacology
Wound Healing--drug effects
Xenograft Model Antitumor Assays
Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Jul 2011 - 4425-38 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1557-3265
10.1158/1078-0432.CCR-10-3339 doi
Animals
Antineoplastic Agents--pharmacology
Carcinoma--metabolism
Carcinoma, Squamous Cell
Cell Line, Tumor
Cell Proliferation--drug effects
ErbB Receptors--antagonists & inhibitors
Female
Gefitinib
Head and Neck Neoplasms--metabolism
Hepatocyte Growth Factor--metabolism
Humans
Mice
Mice, SCID
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Neoplasm Invasiveness
Neoplasms, Squamous Cell--metabolism
Phosphorylation--drug effects
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Proto-Oncogene Proteins c-met--antagonists & inhibitors
Quinazolines--pharmacology
Signal Transduction--drug effects
Squamous Cell Carcinoma of Head and Neck
Transforming Growth Factor alpha--pharmacology
Wound Healing--drug effects
Xenograft Model Antitumor Assays