The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

Aurelio, Luigi

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor. [electronic resource] - Bioorganic & medicinal chemistry letters Jun 2011 - 3704-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3405

10.1016/j.bmcl.2011.04.080 doi


Allosteric Regulation--drug effects
Amines--chemical synthesis
Animals
CHO Cells
Cells, Cultured
Cricetinae
Cricetulus
Cyclization--drug effects
Inhibitory Concentration 50
Molecular Structure
Receptor, Adenosine A1--metabolism
Structure-Activity Relationship
Thiophenes--chemical synthesis