Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

Furman, Phillip A

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661. [electronic resource] - Antiviral research Aug 2011 - 120-32 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1872-9096

10.1016/j.antiviral.2011.05.003 doi


Antiviral Agents--pharmacology
Biotransformation
Cathepsin A--metabolism
Chromatography, High Pressure Liquid
Cloning, Molecular
Drug Evaluation, Preclinical
Guanosine Monophosphate--analogs & derivatives
Guanylate Kinases--metabolism
Hep G2 Cells
Hepacivirus--drug effects
Hepatocytes--drug effects
Humans
Lactic Acid--metabolism
Luciferases--metabolism
Microbial Sensitivity Tests
Mitochondria--drug effects
Mutation
Nerve Tissue Proteins--metabolism
Phenol--metabolism
Phosphorylation
Prodrugs--chemistry
Replicon
Viral Nonstructural Proteins--antagonists & inhibitors
Virus Replication--drug effects