Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.

Ahmed, A

Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. [electronic resource] - Cell death & disease May 2011 - e160 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/cddis.2011.42 doi


Apoptosis--drug effects
Ataxia Telangiectasia--metabolism
Breast Neoplasms--genetics
Cell Cycle Proteins--genetics
Cell Line, Tumor
Checkpoint Kinase 1
Colorectal Neoplasms--genetics
DNA Damage--drug effects
DNA Replication--drug effects
Female
Furans--pharmacology
Gene Knockdown Techniques
Histones--genetics
Humans
Hypoxia--genetics
Hypoxia-Inducible Factor 1, alpha Subunit--antagonists & inhibitors
Osteosarcoma--genetics
Phosphorylation--drug effects
Protein Kinase Inhibitors--pharmacology
Protein Kinases--biosynthesis
Replication Origin--drug effects
S Phase--drug effects
Signal Transduction--drug effects
Transfection
Tumor Suppressor Protein p53--genetics