Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer.

Lashinger, Laura M

Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer. [electronic resource] - Cancer prevention research (Philadelphia, Pa.) Jul 2011 - 1041-51 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1940-6215

10.1158/1940-6207.CAPR-11-0023 doi


Animals
Antibiotics, Antineoplastic--therapeutic use
Blotting, Western
Body Weight--drug effects
Caloric Restriction
Carcinoma, Pancreatic Ductal--metabolism
Combined Modality Therapy
Disease Models, Animal
Glucose--metabolism
Glucose Tolerance Test
Glycogen Synthase Kinase 3--metabolism
Glycogen Synthase Kinase 3 beta
Immunoenzyme Techniques
Insulin-Like Growth Factor I--metabolism
Male
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases--metabolism
Pancreatic Neoplasms--metabolism
Phosphorylation--drug effects
Proto-Oncogene Proteins c-akt--metabolism
Ribosomal Protein S6 Kinases, 70-kDa--metabolism
STAT3 Transcription Factor--metabolism
Sirolimus--therapeutic use
TOR Serine-Threonine Kinases--metabolism
Tumor Cells, Cultured