ER-α agonist induces conversion of fibroblasts into myofibroblasts, while ER-β agonist increases ECM production and wound tensile strength of healing skin wounds in ovariectomised rats.
Novotný, Martin
ER-α agonist induces conversion of fibroblasts into myofibroblasts, while ER-β agonist increases ECM production and wound tensile strength of healing skin wounds in ovariectomised rats. [electronic resource] - Experimental dermatology Sep 2011 - 703-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1600-0625
10.1111/j.1600-0625.2011.01284.x doi
Animals
Cell Differentiation--drug effects
Cells, Cultured
Estrogen Receptor alpha--agonists
Estrogen Receptor beta--agonists
Extracellular Matrix--drug effects
Female
Fibroblasts--cytology
Human Umbilical Vein Endothelial Cells
Humans
In Vitro Techniques
Myofibroblasts--cytology
Nitriles--pharmacology
Ovariectomy
Phenols--pharmacology
Pyrazoles--pharmacology
Rats
Rats, Sprague-Dawley
Selective Estrogen Receptor Modulators--pharmacology
Skin--drug effects
Tensile Strength--drug effects
Wound Healing--drug effects
ER-α agonist induces conversion of fibroblasts into myofibroblasts, while ER-β agonist increases ECM production and wound tensile strength of healing skin wounds in ovariectomised rats. [electronic resource] - Experimental dermatology Sep 2011 - 703-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1600-0625
10.1111/j.1600-0625.2011.01284.x doi
Animals
Cell Differentiation--drug effects
Cells, Cultured
Estrogen Receptor alpha--agonists
Estrogen Receptor beta--agonists
Extracellular Matrix--drug effects
Female
Fibroblasts--cytology
Human Umbilical Vein Endothelial Cells
Humans
In Vitro Techniques
Myofibroblasts--cytology
Nitriles--pharmacology
Ovariectomy
Phenols--pharmacology
Pyrazoles--pharmacology
Rats
Rats, Sprague-Dawley
Selective Estrogen Receptor Modulators--pharmacology
Skin--drug effects
Tensile Strength--drug effects
Wound Healing--drug effects