In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5).

Wanger-Baumann, Cindy A

In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5). [electronic resource] - NeuroImage Jun 2011 - 984-91 p. digital

Publication Type: Journal Article

1095-9572

10.1016/j.neuroimage.2011.03.024 doi


Animals
Autoradiography
Biotransformation
Blood-Brain Barrier--physiology
Brain--anatomy & histology
Brain Chemistry
Cell Line
Cell Membrane Permeability
Fluorine Radioisotopes
Humans
Image Processing, Computer-Assisted
In Vitro Techniques
Isotope Labeling
Male
Microsomes, Liver--metabolism
Oximes--chemical synthesis
Positron-Emission Tomography--methods
Pyridines--chemical synthesis
Radiopharmaceuticals--chemical synthesis
Rats
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate--metabolism
Tissue Distribution
Whole Body Imaging