From target selection to the minimum acceptable biological effect level for human study: use of mechanism-based PK/PD modeling to design safe and efficacious biologics.

Yu, Jing

From target selection to the minimum acceptable biological effect level for human study: use of mechanism-based PK/PD modeling to design safe and efficacious biologics. [electronic resource] - The AAPS journal Jun 2011 - 169-78 p. digital

Publication Type: Journal Article

1550-7416

10.1208/s12248-011-9256-y doi


Animals
Antibodies, Monoclonal--administration & dosage
Cytomegalovirus--immunology
Dose-Response Relationship, Drug
Drug Delivery Systems
Drug Design
Feasibility Studies
Glycoproteins--immunology
Humans
Immunologic Factors--administration & dosage
Macaca fascicularis
Models, Biological
Species Specificity
Translational Research, Biomedical--methods