Biological properties of androgen receptor pure antagonist for treatment of castration-resistant prostate cancer: optimization from lead compound to CH5137291.

Kawata, Hiromitsu

Biological properties of androgen receptor pure antagonist for treatment of castration-resistant prostate cancer: optimization from lead compound to CH5137291. [electronic resource] - The Prostate Sep 2011 - 1344-56 p. digital

Publication Type: Comparative Study; Journal Article

1097-0045

10.1002/pros.21351 doi


Androgen Antagonists--pharmacokinetics
Androgen Receptor Antagonists--administration & dosage
Anilides--pharmacokinetics
Animals
Antineoplastic Agents--pharmacology
Carbamates--pharmacology
Cell Nucleus--metabolism
Cell Proliferation--drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Humans
Lead
Male
Mice
Mice, Nude
Mice, SCID
Neoplasm Transplantation
Nitriles--metabolism
Orchiectomy
Prostatic Neoplasms--metabolism
Receptors, Androgen--drug effects
Sulfonamides--administration & dosage
Thiohydantoins--administration & dosage
Tosyl Compounds--pharmacokinetics
Transcription, Genetic--drug effects
Translocation, Genetic
Transplantation, Heterologous