Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.

Huang, Zhangjian

Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies. [electronic resource] - Journal of medicinal chemistry Mar 2011 - 1356-64 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm101403g doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--adverse effects
Carrageenan
Cyclooxygenase Inhibitors--adverse effects
Edema--chemically induced
Esters
Gastric Mucosa--drug effects
Humans
Hydroxamic Acids--adverse effects
Ibuprofen--adverse effects
Indomethacin--adverse effects
Male
Naproxen--adverse effects
Nitric Oxide Donors--adverse effects
Nitrogen Oxides--metabolism
Prodrugs--adverse effects
Rats
Rats, Sprague-Dawley
Stereoisomerism
Stomach Ulcer--chemically induced
Structure-Activity Relationship