Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells.

Jeannot, Emmanuelle

Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. [electronic resource] - Cancer letters Feb 2011 - 161-7 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1872-7980

10.1016/j.canlet.2010.11.010 doi


Adenoma, Liver Cell--chemically induced
Animals
Cell Proliferation--drug effects
Central Nervous System Depressants--administration & dosage
DNA Damage
Dose-Response Relationship, Drug
Ethanol--administration & dosage
Gene Frequency
Hepatitis, Alcoholic--etiology
Immunohistochemistry
Liver--drug effects
Liver Neoplasms, Experimental--chemically induced
Male
Mice
Mice, Inbred Strains
Mutagenesis--drug effects
Oxidative Stress--drug effects
Proliferating Cell Nuclear Antigen--analysis
Time Factors
beta Catenin--metabolism
ras Proteins--genetics