Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.

Kuck, Dirk

Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. [electronic resource] - Molecular cancer therapeutics Nov 2010 - 3015-23 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-8514

10.1158/1535-7163.MCT-10-0609 doi


Antineoplastic Agents--pharmacology
DNA (Cytosine-5-)-Methyltransferases--antagonists & inhibitors
DNA Methylation--drug effects
Drug Evaluation, Preclinical
Enzyme Inhibitors--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Gene Silencing--drug effects
Genes, Tumor Suppressor--drug effects
HCT116 Cells
HL-60 Cells
HeLa Cells
Humans
Inhibitory Concentration 50
Models, Biological
Naphthoquinones--pharmacology
Neoplasms--genetics
Substrate Specificity
Transcriptional Activation--drug effects
Tumor Cells, Cultured
DNA Methyltransferase 3B