17α-alkynyl 3α, 17β-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism.

Ahlem, Clarence

17α-alkynyl 3α, 17β-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism. [electronic resource] - Investigational new drugs Feb 2012 - 59-78 p. digital

Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study

1573-0646

10.1007/s10637-010-9517-0 doi


Administration, Oral
Androstanols--administration & dosage
Androstenedione--blood
Animals
Antineoplastic Agents, Hormonal--administration & dosage
Biotransformation
Cell Line, Tumor
Chromatography, Liquid
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--biosynthesis
Dehydroepiandrosterone--blood
Dogs
Drug Administration Schedule
Enzyme Induction
Enzyme Inhibitors--pharmacology
Female
Humans
Macaca fascicularis
Male
Metabolomics
Mice
Microsomes, Liver--drug effects
Prostatic Neoplasms--drug therapy
Rats
Rats, Sprague-Dawley
Receptors, Cytoplasmic and Nuclear--drug effects
Species Specificity
Tandem Mass Spectrometry
Testosterone--blood
Transcriptional Activation--drug effects
Transfection