The complement component C5a is present in human coronary lesions in vivo and induces the expression of MMP-1 and MMP-9 in human macrophages in vitro.

Speidl, Walter S

The complement component C5a is present in human coronary lesions in vivo and induces the expression of MMP-1 and MMP-9 in human macrophages in vitro. [electronic resource] - FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan 2011 - 35-44 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1530-6860

10.1096/fj.10-156083 doi


Cells, Cultured
Complement C5a--genetics
Coronary Vessels--metabolism
Fluorescent Antibody Technique
Gene Expression--drug effects
Humans
Immunohistochemistry
Macrophages--drug effects
Masoprocol--pharmacology
Matrix Metalloproteinase 1--genetics
Matrix Metalloproteinase 9--genetics
NF-kappa B--antagonists & inhibitors
Plaque, Atherosclerotic--metabolism
Quinazolines--pharmacology
RNA, Messenger--genetics
Receptor, Anaphylatoxin C5a--metabolism
Recombinant Proteins--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factor AP-1--antagonists & inhibitors