Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.

Abusnina, Abdurazzag

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis. [electronic resource] - Cellular signalling Jan 2011 - 152-60 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-3913

10.1016/j.cellsig.2010.08.015 doi


Antineoplastic Agents--pharmacology
Apoptosis
Benzoquinones--pharmacology
CCAAT-Enhancer-Binding Proteins--metabolism
Cell Cycle Proteins--metabolism
Cell Line
Cyclic Nucleotide Phosphodiesterases, Type 1--antagonists & inhibitors
DNA-Binding Proteins--metabolism
Down-Regulation
Humans
Isoenzymes--genetics
Jurkat Cells
Nuclear Proteins--metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma--enzymology
RNA Interference
Tumor Protein p73
Tumor Suppressor Proteins--metabolism
Ubiquitin-Protein Ligases